Delvac Oceandy Selected Research

Plasma Membrane Calcium-Transporting ATPases

6/2022	Treatment with specific and pan-plasma membrane calcium ATPase (PMCA) inhibitors reduces malaria parasite growth in vitro and in vivo.
7/2021	The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria.
3/2016	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy.
10/2014	Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.
1/2013	Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump--a novel therapeutic target for contraception and malaria.
12/2012	Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.

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Delvac Oceandy Research Topics

Disease

11	Cardiomegaly (Heart Hypertrophy) 01/2020 - 04/2009
8	Hypertrophy 01/2020 - 08/2009
5	Heart Failure 01/2020 - 04/2009
5	Neoplasms (Cancer) 01/2020 - 07/2004
3	Malaria 06/2022 - 01/2013
3	Fibrosis (Cirrhosis) 12/2019 - 07/2013
2	Infections 06/2022 - 07/2021
2	Bradycardia 01/2020 - 10/2017
2	Breast Neoplasms (Breast Cancer) 10/2014 - 12/2012
2	Heart Diseases (Heart Disease) 07/2013 - 05/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 08/2011 - 10/2007
1	Breakthrough Infections 01/2022
1	COVID-19 01/2022
1	Erectile Dysfunction 10/2021
1	Cerebral Malaria 07/2021
1	Diabetes Mellitus 11/2017
1	Pathologic Neovascularization 10/2014
1	Cardiomyopathies (Cardiomyopathy) 09/2014
1	Ventricular Dysfunction 09/2014
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 09/2014
1	Multiple Sclerosis 07/2013
1	Infertility (Sterility) 01/2013
1	Hypertension (High Blood Pressure) 08/2011
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 08/2011
1	Mitral Valve Prolapse 10/2007
1	Herpes Zoster 01/2007

Drug/Important Bio-Agent (IBA)

9	CalciumIBA 06/2022 - 05/2006
7	Proteins (Proteins, Gene)FDA Link 06/2022 - 07/2004
6	Plasma Membrane Calcium-Transporting ATPasesIBA 06/2022 - 12/2012
6	Protein Isoforms (Isoforms)IBA 10/2013 - 01/2007
4	Adenosine Triphosphatases (ATPase)IBA 06/2022 - 01/2007
4	Phosphotransferases (Kinase)IBA 10/2019 - 04/2009
3	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 10/2019 - 08/2014
3	Calmodulin (Calcium-Dependent Activator Protein)IBA 10/2013 - 01/2007
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2020 - 04/2009
2	MicroRNAs (MicroRNA)IBA 01/2020 - 10/2017
2	Ion Channels (Ion Channel)IBA 01/2020 - 10/2017
2	CalcineurinIBA 10/2014 - 12/2012
1	Pharmaceutical PreparationsIBA 06/2022
1	Antimalarials (Antimalarial Agents)IBA 06/2022
1	VaccinesIBA 01/2022
1	Viral VaccinesIBA 01/2022
1	NucleotidesIBA 07/2021
1	AntigensIBA 07/2021
1	Messenger RNA (mRNA)IBA 01/2020
1	CytokinesIBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Interleukin-10 ReceptorsIBA 01/2020
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2020
1	Type 2 Angiotensin ReceptorIBA 12/2019
1	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2019
1	CollagenIBA 12/2019
1	XMU-MP-1IBA 10/2019
1	Advanced Glycation End ProductsIBA 11/2017
1	Hyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIBA 10/2017
1	Cyclic Nucleotide-Gated Cation ChannelsIBA 10/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2016
1	Aurintricarboxylic AcidIBA 03/2016
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2014
1	Peptide Hydrolases (Proteases)FDA Link 09/2014
1	Matrix Metalloproteinases (MMPs)IBA 09/2014
1	PeriostinIBA 07/2013
1	Fingolimod Hydrochloride (FTY720)FDA Link 07/2013
1	Immunologic Factors (Immunomodulators)IBA 07/2013
1	Adenosine Triphosphate (ATP)IBA 01/2013
1	Fas Ligand Protein (Fas Ligand)IBA 12/2012
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2012
1	Apoptosis Regulatory ProteinsIBA 12/2012
1	Mitogen-Activated Protein KinasesIBA 03/2010
1	Matrix Metalloproteinase 3 (Stromelysin 1)IBA 10/2007
1	LigandsIBA 01/2007

Therapy/Procedure

2	Therapeutics 10/2021 - 01/2013
1	Intraperitoneal Injections 01/2020
1	Contraception (Birth Control) 01/2013
1	Hormonal Contraception 01/2013